Last data update: Sep 16, 2024. (Total: 47680 publications since 2009)
Records 1-2 (of 2 Records) |
Query Trace: Angelo DOKm [original query] |
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Epidemiology of travel-associated Dengue from 2007 to 2022: A geosentinel analysis
Duvignaud A , Stoney RJ , Angelo DOKm , Chen LH , Cattaneo P , Motta L , Gobbi FG , Bottieau E , Bourque DL , Popescu CP , Glans H , Asgeirsson H , Oliveira-Souto I , Vaughan SD , Amatya B , Norman FF , Waggoner J , Diaz-Menendez M , Beadsworth M , Odolini S , Camprubí-Ferrer D , Epelboin L , Connor BA , Eperon G , Schwartz E , Libman M , Malvy D , Hamer DH , Huits R . J Travel Med 2024 BACKGROUND: Dengue is a leading cause of febrile illness among international travellers. We aimed to describe the epidemiology and clinical characteristics of imported dengue in returning travellers evaluated at GeoSentinel sites from 2007-2022. METHODS: We retrieved GeoSentinel records of dengue among travellers residing in non-endemic countries. We considered dengue confirmed when diagnosed by a positive DENV-specific RT-PCR, positive NS-1 antigen, and/or anti-DENV IgG seroconversion, and probable when diagnosed by single anti-DENV IgM or high titre anti-DENV IgG detection. Severe dengue was defined as evidence of clinically significant plasma leakage or bleeding, organ failure, or shock, according to the 2009 WHO guidance. Complicated dengue was defined as either severe dengue or dengue with presence of any warning sign. Analyses were descriptive. RESULTS: This analysis included 5958 travellers with confirmed (n = 4859; 81.6%) or probable (n = 1099; 18.4%) dengue. The median age was 33 years (range: < 1-91); 3007 (50.5%) travellers were female. The median travel duration was 21 days (interquartile range [IQR]: 15-32). The median time between illness onset and GeoSentinel site visit was 7 days (IQR: 4-15). The most frequent reasons for travel were tourism (67.3%), visiting friends or relatives (12.2%), and business (11.0%). The most frequent regions of acquisition were Southeast Asia (50.4%), South-Central Asia (14.9%), the Caribbean (10.9%), and South America (9.2%). Ninety-five (1.6%) travellers had complicated dengue, of whom 27 (0.5%) had severe dengue, and one died. Of 2710 travellers with data available, 724 (26.7%) were hospitalized. The largest number of cases (n = 835) was reported in 2019. CONCLUSIONS: A broad range of international travellers should be aware of the risk of acquiring dengue and receive appropriate pretravel counselling regarding preventive measures. Prospective cohort studies are needed to further elucidate dengue risk by destination and over time, as well as severe outcomes and prolonged morbidity (long-dengue) due to travel-related dengue. |
Acute hepatitis A in international travelers: A GeoSentinel analysis, 2008-2020
Balogun O , Brown A , Angelo DoKm , Hochberg NS , Barnett ED , Nicolini LA , Asgeirsson H , Grobusch MP , Leder K , Salvador F , Chen L , Odolini S , Daz-Menndez M , Gobbi F , Connor BA , Libman M , Hamer DH . J Travel Med 2022 29 (2) BACKGROUND: Non-immune international travelers are at risk of acquiring hepatitis A. Although hepatitis A vaccination is recommended for unvaccinated travelers to high or intermediate hepatitis A virus endemicity, compliance with this recommendation is not universal. OBJECTIVE: To describe the demographic and travel characteristics of international travelers infected with hepatitis A during travel. METHODS: Available data on travelers with confirmed (positive molecular test) or probable (symptomatic individuals with a single positive IgM test) hepatitis A diagnosed during and after travel from January 2008 to December 2020 were obtained from the GeoSentinel Surveillance Network database. We analyzed demographic and travel characteristics of infected travelers. RESULTS: Among 254 travelers with hepatitis A (185 confirmed and 69 probable), the median age was 28years (interquartile range: 19-40), 150 (59%) were male, and among 54 travelers with information available, 53 (98%) were unvaccinated. The most common reasons for travel included tourism (n=120; 47%) and visiting friends or relatives (VFR) (n=72; 28%). About two-thirds of VFR travelers with hepatitis A (n=50; 69%) were younger than 20years old. Hepatitis A was acquired most frequently in South-Central Asia (n=63; 25%) and sub-Saharan Africa (n=61; 24%), but 16 travelers (6%) acquired hepatitis A in regions with low endemicity including Western Europe (n=7; 3%), the Caribbean (n=6; 2%), and North America (n=3; 1%). Median duration from illness onset to GeoSentinel site presentation was approximately 7days (IQR: 4-14days). Among 88 travelers with information available, 59% were hospitalized. CONCLUSION: Despite availability of highly effective vaccines, travelers still acquire hepatitis A, even when traveling to low-endemicity destinations. Providing pre-departure hepatitis A vaccine to susceptible travelers is crucial to reducing travel-associated hepatitis A and should be offered to all travelers as part of the pre-travel consultation, regardless of destination. |
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