Advanced Molecular Detection Clips Content (Published on 02/18/2021)
NEWS
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A lone infection may have changed the course of the pandemic
Reynolds M. Wired, Feb 10, 2021. -
The coronavirus is here to stay--here's what that means
Phillips N. Nature, FEb 16, 2021. -
7 Virus Variants Found in U.S. Carrying the Same Mutation
Zimmer C. New York Times, Feb 14, 2021. -
COVID-19 virus variants are evolving "escape" mutations, and immune-compromised patients provide a breeding ground
McCullough M. Philadelphia Inquirer, Feb 12, 2021. -
COVID-19 Response Team Warns of Rise in Variants
Walker M. MedPage Today, Feb 17, 2021. -
"Major stones unturned": COVID origin search must continue after WHO report, say scientists
Mallapaty S, et al. Nature, Feb 10. 2021. -
Sewage samples show COVID-19 spreading fast in some French cities
De Clercq G. Reuters, Feb 11, 2021. -
Four people in Oregon who received both doses of vaccine test positive for coronavirus
Burke M. NBC, Feb 13, 2021. -
Guinea reports deadly Ebola outbreak as vaccination begins in DRC
Schnirring L. CIDRAP, Feb 15, 2021. -
In lab experiment, Pfizer-BioNTech vaccine less potent against coronavirus variant
Joseph A. STAT, Feb 17, 2021.
POLICY
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Federal Agencies Collaborate to Solicit Proposals for SARS-CoV-2 Testing Supply Chain Scale-Up
GenomeWeb, Feb 12, 2021. -
Biden Administration Will Provide $1.6B to Improve COVID-19 Testing and Sequencing
GenomeWeb, Feb 17, 2021.
CONCEPTS / COMMENTS
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Genomic-informed pathogen surveillance in Africa: opportunities and challenges.
Inzaule Seth C et al. The Lancet. Infectious diseases 2021 Feb -
The CRISPR revolution and its potential impact on global health security.
Watters Kyle E et al. Pathogens and global health 2021 Feb 1-13 -
Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases.
Jain Shikha et al. Biosensors & bioelectronics 2021 Feb 113074 -
SARS-CoV-2 Variants of Concern in the United States-Challenges and Opportunities.
Walensky Rochelle P et al. JAMA 2021 Feb -
Tracking the UK SARS-CoV-2 outbreak.
Nelson Martha I et al. Science (New York, N.Y.) 2021 02 (6530) 680-681 -
Public health actions to control new SARS-CoV-2 variants
Grubaugh ND, et al. Cell. 2021 Jan 29;S0092-8674(21)00087-8. -
SARS-CoV-2 Viral Variants-Tackling a Moving Target.
Mascola John R et al. JAMA 2021 Feb -
The Missing Science: Epidemiological data gaps for COVID-19 policy in the United States
Bhatia R, et al. medRxiv, Feb 12, 2021.
METHODS / TOOLS
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Protocol for Safe, Affordable, and Reproducible Isolation and Quantitation of SARS-CoV-2 RNA from Wastewater
Trujillo M, et al. medRxiv, Feb 17, 2021. -
An alternative approach for bioanalytical assay development for wastewater-based epidemiology of SARS-CoV-2
Boogaerts T, et al. medRxiv, Feb 13, 2021. -
Effect of low-passage number on dengue consensus genomes and intra-host variant frequencies.
Fung Christian K et al. The Journal of general virology 2021 Feb -
Development of a new barcode-based, multiplex-PCR, next-generation-sequencing assay and data processing and analytical pipeline for multiplicity of infection detection of Plasmodium falciparum.
Mitchell Rebecca M et al. Malaria journal 2021 Feb (1) 92
EVOLUTION / ECOLOGY / POPULATIONS
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Whole-Genome Phylogenetic Analysis Reveals a Wide Diversity of Non-O157 STEC Isolated From Ground Beef and Cattle Feces.
Gutiérrez Sebastián et al. Frontiers in microbiology 2020 622663 -
Ecoepidemiology and Potential Transmission of Vibrio cholerae among Different Environmental Niches: An Upcoming Threat in Egypt.
Ismail Eman M et al. Pathogens (Basel, Switzerland) 2021 Feb (2) -
SARS-CoV-2 evolution during treatment of chronic infection.
Kemp Steven A et al. Nature 2021 Feb -
A SARS-CoV-2 lineage A variant (A.23.1) with altered spike has emerged and is dominating the current Uganda epidemic
Bugembe DL, et al. medRxiv, Feb 11, 2021. -
Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants.
Wang Rui et al. Communications biology 2021 02 (1) 228 -
Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677
Hodcroft EB, et al. medRxiv, Feb 14, 2021. -
Emergence of a Novel SARS-CoV-2 Variant in Southern California.
Zhang Wenjuan et al. JAMA 2021 Feb -
Evolutionary analysis and lineage designation of SARS-CoV-2 genomes
Tang X, et al. Sci Bull (Beijing). 2021 Feb 6. -
Emergence of multiple SARS-CoV-2 mutations in an immunocompromised host
Khatamzas E, et al. medRxiv, Jan 15, 2021. -
Variant analysis of SARS-CoV-2 genomes in the middle east.
Bindayna Khalid Mubarak et al. Microbial pathogenesis 2021 Feb 104741 -
Molecular and clinical characterization of the equine-like G3 rotavirus that caused the first outbreak in Japan, 2016.
Akane Yusuke et al. The Journal of general virology 2021 Feb -
Global patterns of recombination across human viruses.
Patiño-Galindo Juan Ángel et al. Molecular biology and evolution 2021 Feb -
A hotspot of Toxoplasma gondii Africa 1 lineage in Benin: How new genotypes from West Africa contribute to understand the parasite genetic diversity worldwide.
Hamidovic Azra et al. PLoS neglected tropical diseases 2021 Feb (2) e0008980
PATHOGENICITY / ANTIMICROBIAL RESISTANCE
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The mosaic mtr locus as major genetic determinant of azithromycin resistance of Neisseria gonorrhoeae, Germany, 2018.
Banhart Sebastian et al. The Journal of infectious diseases 2021 Feb -
Tracking the Emergence of Azithromycin Resistance in Multiple Genotypes of Typhoidal Salmonella .
Sajib Mohammad S I et al. mBio 2021 Feb (1) -
Identification of drug resistance mutations among Mycobacterium bovis lineages in the Americas.
Vázquez-Chacón Carlos Arturo et al. PLoS neglected tropical diseases 2021 Feb (2) e0009145 -
Uncovering Ways that Emerging SARS-CoV-2 Lineages May Increase Transmissibility.
Lemieux Jacob E et al. The Journal of infectious diseases 2021 Feb -
Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2
Tian F, et al. bioRxiv, Feb 17, 2021. -
Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir.
Patel Mira C et al. Antiviral research 2021 Feb 105035 -
Low prevalence of highly sulfadoxine-resistant dihydropteroate synthase alleles in Plasmodium falciparum isolates in Benin.
Svigel Samaly Souza et al. Malaria journal 2021 Feb (1) 72
DETECTION / DIAGNOSIS
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Bayesian Source Attribution of Salmonella Typhimurium Isolates From Human Patients and Farm Animals in England and Wales.
Arnold Mark et al. Frontiers in microbiology 2021 579888 -
Approaches for characterizing and tracking hospital-associated multidrug-resistant bacteria.
Blake Kevin S et al. Cellular and molecular life sciences : CMLS 2021 Feb -
Genomics accurately predicts antimicrobial resistance in Staphylococcus pseudintermedius collected as part of Vet-LIRN resistance monitoring.
Tyson Gregory H et al. Veterinary microbiology 2021 Feb 109006 -
Before the Surge: Molecular Evidence of SARS-CoV-2 in New York City Prior to the First Report
Hernandez MM, et al. medRxiv, Feb 12, 2021. -
Rapid Rise of S-Gene Target Failure and the UK variant B.1.1.7 among COVID-19 isolates in the Greater Toronto Area, Canada
Brown KA, et al. medRxiv, Feb 12, 2021. -
Inclusion of cycle threshold (CT) values when reporting SARS-CoV-2 RT-PCR results improves clinical Interpretation in suspected and confirmed COVID-19
Coyle PV, et al. medRxiv, Feb 12, 2021. -
S-variant SARS-CoV-2 lineage B1.1.7 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-qPCR.
Kidd Michael et al. The Journal of infectious diseases 2021 Feb -
Evidence of SARS-CoV-2 reinfection without mutations in Spike protein.
Kulkarni Onkar et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Feb -
Simpler and faster Covid-19 testing: Strategies to streamline SARS-CoV-2 molecular assays.
Panpradist Nuttada et al. EBioMedicine 2021 Feb 103236 -
Comparison of Severe Acute Respiratory Syndrome Coronavirus 2 Screening Using Reverse Transcriptase-Quantitative Polymerase Chain Reaction or CRISPR-Based Assays in Asymptomatic College Students.
Rauch Jennifer N et al. JAMA network open 2021 02 (2) e2037129 -
First Identified Cases of SARS-CoV-2 Variant B.1.1.7 in Minnesota--December 2020-January 2021
Firestone MJ, et al. MMWR, Feb 17, 2021. -
Misinterpretation of viral load in COVID-19 clinical outcomes
Miranda RL, et al. Virus Res. 15 April 2021,296:198340 -
One-tube SARS-CoV-2 detection platform based on RT-RPA and CRISPR/Cas12a.
Sun Yangyang et al. Journal of translational medicine 2021 Feb (1) 74 -
Update in natural antiretroviral-associated mutations among HIV-2 variants and discrepancies across HIV-2 resistance interpretation tools.
Troyano-Hernáez Paloma et al. AIDS research and human retroviruses 2021 Feb
EPIDEMIOLOGY / OUTBREAKS / TRANSMISSION
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Sustained Transmission of Neisseria gonorrhoeae with High-Level Resistance to Azithromycin, Indianapolis, Indiana 2017-2018.
Holderman Justin L et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Feb -
Investigation of Serratia marcescens surgical site infection outbreak associated with peroperative ultrasonography probe.
Géry A et al. The Journal of hospital infection 2021 Feb -
Successful containment of two vancomycin-resistant Enterococcus faecium (VRE) outbreaks in a Dutch teaching hospital using environmental sampling and whole genome sequencing.
Gast K B et al. The Journal of hospital infection 2021 Feb -
Serratia marcescens outbreak in a neonatal intensive care unit and the potential of whole-genome sequencing.
Muyldermans Astrid et al. The Journal of hospital infection 2021 Feb -
Early introductions and community transmission of SARS-CoV-2 variant B.1.1.7 in the United States
Alpert T, et al. medRxiv, Feb 12, 2021. -
Genomic epidemiology of COVID-19 in care homes in the East of England
Hamilton WL, et al. medRxiv, Feb 16, 2021. -
Transmission dynamics of SARS-CoV-2 on the Diamond Princess uncovered using viral genome sequence analysis.
Hoshino Kunikazu et al. Gene 2021 Feb 145496 -
The origin and early spread of SARS-CoV-2 in Europe.
Nadeau Sarah A et al. Proceedings of the National Academy of Sciences of the United States of America 2021 03 (9) -
Transmission of SARS-CoV-2 among healthcare workers and patients in a teaching hospital in the Netherlands confirmed by whole genome sequencing.
Paltansing S et al. The Journal of hospital infection 2021 Feb -
An early assessment of the epidemiological effects of SARS-CoV-2 variants of concern in Germany
Mitze TF, Rode J. medRxiv, Feb 16, 2021. -
Detection of B.1.351 SARS-CoV-2 Variant Strain - Zambia, December 2020.
Mwenda Mulenga et al. MMWR. Morbidity and mortality weekly report 2021 2 (8) 280-282 -
Effective HIV Molecular Surveillance Requires Identification of Incident Cases of Infection.
Little Susan J et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Feb -
First complete-genome documentation of HIV-1 intersubtype superinfection with transmissions of diverse recombinants over time to five recipients.
Gao Yang et al. PLoS pathogens 2021 Feb (2) e1009258 -
Parasite genetic diversity reflects continued residual malaria transmission in Vhembe District, a hotspot in the Limpopo Province of South Africa.
Gwarinda Hazel B et al. Malaria journal 2021 Feb (1) 96
ANTIMICROBIALS / VACCINES / INTERVENTIONS
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Safety and efficacy of the ChAdOx1 nCoV-19 (AZD1222) Covid-19 vaccine against the B.1.351 variant in South Africa
Madhi SA, et al. medRxiv, Feb 12, 2021. -
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig Paul-Albert et al. Science (New York, N.Y.) 2021 02 (6530) -
Recombinant Zoster Vaccine (Shingrix) real-world effectiveness in the first two years post-licensure.
Izurieta Hector S et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Feb -
Antibodies for Human Immunodeficiency Virus-1 Cure Strategies.
Rossignol Evan et al. The Journal of infectious diseases 2021 Feb (Supplement_1) 22-31 -
Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection.
Page Kimberly et al. The New England journal of medicine 2021 02 (6) 541-549
HOST-MICROBE INTERACTIONS
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Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition.
Greaney Allison J et al. Cell host & microbe 2021 01 (1) 44-57.e9 -
Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies
Planas D, et al. bioRxiv, Feb 12, 2021. -
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine.
Bastard Paul et al. The Journal of experimental medicine 2021 04 (4) -
Protection and Risk: Male and Female Genital Microbiota and Sexually Transmitted Infections.
Tuddenham Susan et al. The Journal of infectious diseases 2021 Feb


Disclaimer: Articles listed in the Advanced Molecular Detection Clips are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the clips does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2023
- Page last updated:Sep 21, 2023
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