Personalized Medicine in Kidney Disease
G Gembilo et al, JPM, October 16, 2023
From the abstract: "Personalized medicine uses the phenotypes and genotypes of individuals to tailor the best therapeutic approach for each patient at the appropriate time, to identify a person’s propensity for disease, and/or to provide timely and targeted prevention. In the context of kidney diseases, it has the potential to completely transform patient care on the basis of individual traits and needs. In particular, personalized medicine approaches in chronic kidney disease (CKD) aim to tailor treatment strategies based on underlying causes, genetic factors, the rate of disease progression, and other personalized factors. "
CKD Risk Factors
CDC, June 2023
Diabetes and high blood pressure are the more common causes of CKD in most adults. Other risk factors include heart disease, obesity, a family history of CKD, inherited kidney disorders, past damage to the kidneys, and older age.
Non-invasive chronic kidney disease risk stratification tool derived from retina-based deep learning and clinical factors.
Young Su Joo et al. NPJ Digit Med 2023 6 (1) 114
Despite the importance of preventing chronic kidney disease (CKD), predicting high-risk patients who require active intervention is challenging, especially in people with preserved kidney function. In this study, a predictive risk score for CKD (Reti-CKD score) was derived from a deep learning algorithm using retinal photographs. The performance of the Reti-CKD score was verified using two longitudinal cohorts of the UK Biobank and Korean Diabetic Cohort.
Biomarkers and personalised medicine in paediatric kidney disease
BL Neuen, The Lancet Ped Adol Med, June 2023
The concept of precision medicine for children and adults with chronic kidney disease has gained considerable attention in the past decade, with improvements in our understanding of the genetic, molecular, and other mechanisms that drive disease predisposition and progression. A notable example is the US National Institute of Diabetes and Digestive and Kidney Diseases' Kidney Precision Medicine Project,