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Last Posted: Jun 20, 2024
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Genetics of chronic respiratory disease.
Ian Sayers et al. Nat Rev Genet 2024 3

From the abstract: "Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and interstitial lung diseases are frequently occurring disorders with a polygenic basis that account for a large global burden of morbidity and mortality. Recent large-scale genetic epidemiology studies have identified associations between genetic variation and individual respiratory diseases and linked specific genetic variants to quantitative traits related to lung function. "

The infant gut virome is associated with preschool asthma risk independently of bacteria
CL Rodriguez et al, Nature Medicine, December 15, 2023

From the abstract: "Here, we analyze the gut virome of 647 children aged 1?year from the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) mother–child cohort, all deeply phenotyped from birth and with longitudinally assessed asthma diagnoses. Specific temperate gut phage taxa were found to be associated with later development of asthma. In particular, the joint abundances of 19 caudoviral families were found to significantly contribute to this association. Combining the asthma-associated virome and bacteriome signatures had additive effects on asthma risk."

Cord blood DNA methylation signatures associated with preeclampsia are enriched for cardiovascular pathways: insights from the VDAART trial.
Hanna M Knihtilä et al. EBioMedicine 2023 11 104890

From the abstract: "Preeclampsia has been associated with maternal epigenetic changes, in particular DNA methylation changes in the placenta. It has been suggested that preeclampsia could also cause DNA methylation changes in the neonate. We examined DNA methylation in relation to gene expression in the cord blood of offspring born to mothers with preeclampsia. This study included 128 mother-child pairs who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), where assessment of preeclampsia served as secondary outcome. We found that preeclampsia is related to differential cord blood DNA methylation signatures of cardiovascular pathways, including the apelin signaling pathway. "

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